The potential of conjugated linoleic acid (CLA) as an anti-obesity molecule for humans is still a matter for debate. Thus, a great deal of scientific work is focussed on the research of new effective molecules without deleterious effects on health. The aim of the present work was to analyse the effects of jacaranda seed oil, rich in a conjugated linolenic acid (CLNA), jacaric acid (cis-8,trans-10,cis-12), on body fat, serum parameters and liver composition in rats, and to compare these effects with those oftrans-10,cis-12 CLA. Twenty-six male Wistar rats were divided into three groups fed with high-fat diets, supplemented or not (control group) with 0.5%trans-10,cis-12 CLA (CLA group) or 0.5% jacaric acid (CLNA group) for 7 weeks. No statistical differences in food intake or in final body weight were found. Whereas CLA reduced adipose tissue size, CLNA did not. Both CLA and CLNA significantly reduced non-HDL-cholesterol. In spite of a lack of significant changes in glucose and insulin levels, HOMA-IR index was significantly increased, as well as did non-esterified fatty acid levels in CLNA-fed rats. No changes in liver composition were observed. In conclusion, under our experimental conditions, jacaric acid, unlike CLA, does not show a body-fat lowering effect. Even though it leads to a healthy lipoprotein profile, it impairs insulin function. Consequently, it cannot be proposed as an anti-obesity molecule.

中文翻译：

---

CLNA 和 CLA 对体脂、血清参数和肝脏成分的影响的比较。

共轭亚油酸 (CLA) 作为人类抗肥胖分子的潜力仍然存在争议。因此，大量的科学工作集中在对健康没有有害影响的新有效分子的研究上。本工作的目的是分析蓝花楹籽油，富含共轭亚麻酸 (CLNA)、蓝花楹酸（顺式-8、反式-10、顺式-12）对体脂、血清参数和肝脏的影响。大鼠中的成分，并将这些效果与反式-10、顺式-12 CLA 的效果进行比较。将 26 只雄性 Wistar 大鼠分为三组，饲喂高脂饮食，补充或不补充（对照组）0.5%反式-10，顺式-12 CLA（CLA组）或0.5%紫杉酸（CLNA组）7周。没有发现食物摄入量或最终体重的统计学差异。CLA 减少了脂肪组织的大小，而 CLNA 则没有。CLA 和 CLNA 都显着降低了非高密度脂蛋白胆固醇。尽管葡萄糖和胰岛素水平没有显着变化，但 HOMA-IR 指数显着增加，CLNA 喂养大鼠的非酯化脂肪酸水平也显着增加。未观察到肝脏成分的变化。总之，在我们的实验条件下，与 CLA 不同的是，紫杉酸没有显示出降低体脂的作用。尽管它会导致健康的脂蛋白分布，但它会损害胰岛素功能。因此，它不能被提议作为抗肥胖分子。