The genetic epidemiology of sporadic Alzheimer's disease (SAD) remains a very active area of research, making it one of the most prolifically published areas in medicine and biology. Numerous putative candidate genes have been proposed. However, with the exception of apolipoprotein E (APOE), the only confirmed genetic risk factor for SAD, all the other data appear to be not consistent. Nevertheless, the genetic risk for SAD attributable to the APOE gene in the general population is 20–70%, providing a strong evidence for the existence of additional genetic risk factors. The first part of the present article was dedicated to non-APOE genetics of SAD, reviewing chromosomes-by-chromosomes the available data concerning the major candidate genes. The second part of this article focused on some recently discovered aspects of the APOE polymorphism and their implications for SAD. An attempt to identify the future directions for non-APOE genetic research in SAD was also discussed.

散发性阿尔茨海默氏病（SAD）的遗传流行病学仍然是一个非常活跃的研究领域，使其成为医学和生物学领域发表最多的领域之一。已经提出了许多推定的候选基因。但是，除了载脂蛋白E（APOE）（唯一确定的SAD遗传危险因素）外，所有其他数据似乎不一致。然而，一般人群中归因于APOE基因的SAD遗传风险为20％至70％，这为存在其他遗传风险因素提供了有力的证据。本文的第一部分专门针对SAD的非APOE遗传学，回顾了逐染色体的有关主要候选基因的可用数据。本文的第二部分重点介绍了APOE多态性的一些最近发现的方面及其对SAD的影响。还讨论了为SAD中非APOE基因研究确定未来方向的尝试。