Myeloproliferative neoplasms are hematological malignancies frequently associated with somatically acquired mutation of the JAK2 gene. A new study shows that these mutations are preferentially found within a particular inherited JAK2 haplotype, implying the existence of a strong, but uncharacterized, interaction between somatic and germline genetics at this locus.

中文翻译：

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JAK2 基因座的体细胞和种系遗传学。

骨髓增生性肿瘤是血液系统恶性肿瘤，通常与 JAK2 基因的体细胞获得性突变相关。一项新研究表明，这些突变优先在特定的遗传 JAK2 单倍型中发现，这意味着在该位点的体细胞和种系遗传之间存在强烈但未表征的相互作用。