The life of any protein within a cell begins with transcriptional activation, and ends with proteolytic degradation. Intriguingly, the 26S proteasome complex, a non-lysosomal protein degradation machine comprising the 20S proteolytic core and 19S regulatory particles, has been implicated in intimate regulation of eukaryotic transcriptional activation through diverse mechanisms in a proteolysis-dependent as well as independent manner. Here, we discuss the intricate mechanisms of such proteasomal regulation of eukaryotic gene activation via multiple pathways.

中文翻译：

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蛋白酶体复合体对真核转录激活的不同调控机制。

细胞内任何蛋白质的生命都始于转录激活，并最终发生蛋白水解降解。有趣的是，包含20S蛋白水解核心和19S调节颗粒的26S蛋白酶体复合物是一种非溶酶体蛋白降解机器，已通过依赖于蛋白水解以及独立方式的多种机制参与了对真核转录激活的紧密调节。在这里，我们讨论了通过多种途径对真核基因激活进行蛋白酶体调节的复杂机制。