The vinca alkaloids are neurotoxic, usually causing a peripheral neuropathy, but cranial neuropathies are rare as side effects. We describe a case of vincristine-induced multiple cranial and autonomic neuropathy, and sensory-motor axonal peripheral neuropathy (pan-neuropathy), which is an extremely rare fatal complication of this drug. The patient developed fulminant cranial, peripheral and significant autonomic neuropathy.

中文翻译：

---

长春新碱在非霍奇金淋巴瘤中引起的致命性神经病。

长春花生物碱具有神经毒性，通常会引起周围神经病变，但颅神经病变很少作为副作用。我们描述了一个长春新碱致多发性颅神经和自主神经病变以及感觉运动轴突周围神经病变（泛神经病）的病例，这是该药物极为罕见的致命并发症。患者发展为暴发性颅脑，周围神经和明显的自主神经病变。