In the past ten years since the discovery and cloning of members of the P2 receptor family, rapid progress has been made in the field regarding the function and pharmacology of different P2 receptor subtypes. This research resulted in identifying these receptors as important players in the pathology of atherosclerosis, cystic fibrosis, neurodegenerative and autoimmune diseases, among other disorders. The signalling mechanisms whereby P2 receptors mediate pathogenesis are not clear in most cases. Future studies in this field will focus on the integration of signalling pathways coupled to P2 receptors and the generation of specific agonists/antagonists for each receptor subtype to provide strategies for the treatment of a variety of diseases.

中文翻译：

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健康和疾病中的P2受体。

自发现和克隆P2受体家族成员以来的过去十年中，关于不同P2受体亚型的功能和药理学，该领域已取得了迅速的进步。这项研究的结果是确定这些受体在动脉粥样硬化，囊性纤维化，神经退行性疾病和自身免疫性疾病等疾病的病理中起重要作用。在大多数情况下，P2受体介导发病机理的信号传导机制尚不清楚。该领域的未来研究将集中于与P2受体偶联的信号传导途径的整合，以及针对每种受体亚型的特异性激动剂/拮抗剂的产生，从而为多种疾病的治疗提供策略。