A bioartificial endocrine pancreas is proposed as a future alternative to current treatment options. Patients with insulin-secretion deficiency might benefit. This is the first systematic review that provides an overview of scaffold materials and techniques for insulin-secreting cells or cells to be differentiated into insulin-secreting cells. An electronic literature survey was conducted in PubMed/MEDLINE and Web of Science, limited to the past 10 years. A total of 197 articles investigating 60 different materials met the inclusion criteria. The extracted data on materials, cell types, study design, and transplantation sites were plotted into two evidence gap maps. Integral parts of the tissue engineering network such as fabrication technique, extracellular matrix, vascularization, immunoprotection, suitable transplantation sites, and the use of stem cells are highlighted. This systematic review provides an evidence-based structure for future studies. Accumulating evidence shows that scaffold-based tissue engineering can enhance the viability and function or differentiation of insulin-secreting cells both in vitro and in vivo.

中文翻译：

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胰腺组织工程的新兴领域：胰岛素分泌细胞支架材料和支架技术的系统回顾和证据图。

生物人工内分泌胰腺被提议作为当前治疗方案的未来替代方案。胰岛素分泌不足的患者可能会受益。这是第一次系统综述，概述了胰岛素分泌细胞或细胞分化为胰岛素分泌细胞的支架材料和技术。在 PubMed/MEDLINE 和 Web of Science 上进行了电子文献调查，仅限于过去 10 年。共有 197 篇研究 60 种不同材料的文章符合纳入标准。提取的有关材料、细胞类型、研究设计和移植部位的数据被绘制成两个证据差距图。重点介绍了组织工程网络的组成部分，例如制造技术、细胞外基质、血管化、免疫保护、合适的移植位点和干细胞的使用。该系统综述为未来的研究提供了基于证据的结构。越来越多的证据表明，基于支架的组织工程可以在体外和体内增强胰岛素分泌细胞的活力和功能或分化。