Abstract

Massive pro-inflammatory cytokines production has been correlated with the pathogenesis of severe dengue disease. The active compound of mangosteen fruit pericarps, α-mangostin, has been commonly used as traditional medicine and dietary supplement. We examined the effect of α-mangostin against dengue virus (DENV) infection in human peripheral blood mononuclear cells (PBMC) by the measurement of virus titer and TNF-α and IFN-γ cytokines concentration post infection. Increasing concentration of α-mangostin inhibited virus replication and reduced inflammatory cytokines expression at 24- and 48-h post infection. Our results support the potential use of α-mangostin as anti-antiviral and anti-inflammatory therapies in the treatment of dengue.

Graphic Abstract

中文翻译：

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Alman-Mangostin对人外周血单个核细胞中登革热病毒复制和细胞因子表达的抑制作用。

摘要

大量促炎细胞因子的产生与严重登革热疾病的发病机理有关。山竹果皮的活性化合物α-芒果，已被普遍用作传统药物和膳食补充剂。我们通过测量病毒滴度以及感染后TNF-α和IFN-γ细胞因子的浓度，检查了α-芒果素对人外周血单核细胞（PBMC）中登革热病毒（DENV）感染的影响。感染后24小时和48小时，α-Mangostin浓度的增加会抑制病毒复制并降低炎性细胞因子的表达。我们的研究结果支持α-Mangostin在登革热治疗中作为抗病毒和抗炎疗法的潜在用途。

图形摘要