Aurantiadioic acids A (1) and B (2), two new furan-containing polyketides, and aurantoic acid A (3), a new natural product, were isolated from the liquid fermentation of the sika deer dung-derived actinomycete Actinocorallia aurantiaca. The structures of the new compounds were established by extensive spectroscopic methods, including 1D & 2D NMR, HRESIMS spectroscopic analysis. The absolute configuration of 3 was assigned by comparison of the specific optical rotations with the reported derivatives. Biological activity evaluations suggested that compounds 1–3 showed weak inhibition on NO production in the murine monocytic RAW 264.7 macrophages with IC₅₀ values of 35.8, 41.8, 45.2 μM, respectively. Compound 3 showed weak inhibition on influenza A virus (A/PuertoRico/8/1934, H1N1) with an EC₅₀ value of 35.9 μM, and a selective index higher than 13.3.

中文翻译：

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放线菌放线放线放线菌的三种新化合物。

Aurantiadioic酸A（1）和B（2），两个新的含呋喃的聚酮化合物，和aurantoic酸A（3），一个新的天然产物，从液体中分离发酵梅花鹿粪便来源的放线菌Actinocorallia aurantiaca。新化合物的结构通过广泛的光谱方法建立，包括1D和2D NMR，HRESIMS光谱分析。通过将特定旋光度与报告的导数进行比较，可以确定3的绝对构型。生物活性评价表明，化合物1 - 3显示出对NO产生抑制作用较弱在鼠单核细胞RAW与IC 264.7巨噬细胞_50个值分别为35.8、41.8和45.2μM。化合物3对A型流感病毒（A / PuertoRico / 8/1934，H1N1）的抑制作用较弱，EC ₅₀值为35.9μM ，选择性指数高于13.3。