The decision by public health agencies to regulate specific microorganisms that may be found in drinking water can only be made if specific criteria find that a microorganism poses a health risk. These criteria should include: (1) there is a clinical history of an organism causing disease from the ingestion of drinking water; (2) there is epidemiological evidence that drinking water rather than food or other vectors is a major source of disease; (3) there is sufficient evidence that the target organism, if found in water, possesses virulence factors capable of causing disease in humans; (4) there is sufficient evidence that the target organism is not readily removed or inactivated by multi-barrier conventional water treatment process (e.g., coagulation-filtration-disinfection); (5) there is sufficient evidence that the target organism, if surviving conventional treatment, will be viable, virulent, and present in sufficient numbers to cause disease; (6) there are robust analytical methods for the target organism which have acceptable sensitivity, specificity, and reproducibility to measure accurately the presence of the target organism in treated water; and (7) the performance criteria of analytical method(s) for the target organism have been certified by the appropriate public health agency, and there is intra-laboratory field-test performance data to base this certification.

中文翻译：

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微生物调节的问题：气单胞菌为模型。

公共卫生机构只有在特定标准发现微生物构成健康风险的情况下，才能对饮用水中可能存在的特定微生物进行管理。这些标准应包括：（1）有生物的临床病史，其原因是食入饮用水引起疾病；（2）有流行病学证据表明，饮用水而不是食物或其他媒介是主要的疾病来源；（3）有充分的证据表明，如果目标生物存在于水中，则具有能够引起人类疾病的毒力因子；（4）有足够的证据表明目标生物不易通过多屏障常规水处理工艺（例如，凝结-过滤-消毒）去除或失活；（5）有足够的证据证明目标生物，如果幸存于常规治疗中，则将是可行的，有毒的，并以足以引起疾病的数量存在；（6）有针对目标生物的可靠分析方法，具有可接受的灵敏度，特异性和可重复性，可以准确地测量处理后的水中目标生物的存在；（7）目标微生物的分析方法的性能标准已经由相应的公共卫生机构认证，并且实验室内部的现场测试性能数据以此认证为基础。可重复性，以准确测量处理后的水中目标微生物的存在；（7）目标微生物的分析方法的性能标准已经由相应的公共卫生机构认证，并且实验室内部的现场测试性能数据以此认证为基础。可重复性，以精确测量处理过的水中目标生物的存在；（7）目标微生物的分析方法的性能标准已经由相应的公共卫生机构认证，并且实验室内部的现场测试性能数据以此认证为基础。