Fast synaptic inhibition in the brain and spinal cord is mediated largely by ionotropic gamma-aminobutyric acid (GABA) receptors. GABAA receptors play a key role in controlling neuronal activity; thus modulating their function will have important consequences for neuronal excitation. GABAA receptors are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are involved in a number of CNS diseases, including sleep disturbances, anxiety, premenstrual syndrome, alcoholism, muscle spasms, Alzheimer's disease, chronic pain, schizophrenia, bipolar affective disorders, and epilepsy. This review focuses on the functional and pharmacological properties of GABAA receptors and trafficking as an essential mechanism underlying the dynamic regulation of synaptic strength.

中文翻译：

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GABAA受体：性质和贩运。

在大脑和脊髓中快速的突触抑制主要由离子型γ-氨基丁酸（GABA）受体介导。GABAA受体在控制神经元活动中起关键作用。因此，调节其功能将对神经元兴奋产生重要影响。GABAA受体是一系列镇静剂，抗焦虑药和催眠药的重要治疗靶标，并参与许多中枢神经系统疾病，包括睡眠障碍，焦虑症，经前综合症，酒精中毒，肌肉痉挛，阿尔茨海默氏病，慢性疼痛，精神分裂症，双相性情感障碍和癫痫病。这篇综述着重于GABAA受体的功能和药理特性以及作为动态调节突触强度的基本机制的运输。