Metazoan development relies on a highly regulated network of interactions between conserved signal transduction pathways to coordinate all aspects of cell fate specification, differentiation, and growth. In this review, we discuss the intricate interplay between the epidermal growth factor receptor (EGFR; Drosophila EGFR/DER) and the Notch signaling pathways as a paradigm for signal integration during development. First, we describe the current state of understanding of the molecular architecture of the EGFR and Notch signaling pathways that has resulted from synergistic studies in vertebrate, invertebrate, and cultured cell model systems. Then, focusing specifically on the Drosophila eye, we discuss how cooperative, sequential, and antagonistic relationships between these pathways mediate the spatially and temporally regulated processes that generate this sensory organ. The common themes underlying the coordination of the EGFR and Notch pathways appear to be broadly conserved and should, therefore, be directly applicable to elucidating mechanisms of information integration and signaling specificity in vertebrate systems.

中文翻译：

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发育过程中的信号整合：EGFR和Notch通路功能与串扰的机制。

后生动物的发展依赖于保守信号转导途径之间相互作用的高度调控网络，以协调细胞命运规范，分化和生长的各个方面。在这篇综述中，我们讨论了表皮生长因子受体（EGFR;果蝇EGFR / DER）与Notch信号通路之间复杂的相互作用，作为开发过程中信号整合的范例。首先，我们描述了对脊椎动物，无脊椎动物和培养的细胞模型系统的协同研究所产生的对EGFR和Notch信号通路分子结构的了解的当前状态。然后，我们专门针对果蝇眼，讨论如何协作，顺序，这些途径之间的拮抗关系介导了产生这种感觉器官的时空调节过程。EGFR和Notch途径协调的共同主题似乎被广泛保留，因此应直接适用于阐明脊椎动物系统中信息整合和信号特异性的机制。