In mycobacteria, iron dependent transcription regulator (IdeR) regulates transcription of genes in response to iron levels. The IdeR regulated genes have been investigated mostly in M. tuberculosis, M. smegmatis, and in few of the other related species. Recent advances in crystal structure solution and computational as well as experimental identification of IdeR targets has provided insight into IdeR structure and function. Here in this review we take stock of current state of knowledge on IdeR and its targets to understand the underlying design of the IdeR regulon and its role in mycobacterial physiology.

中文翻译：

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分枝杆菌中的IdeR：从靶标识别到生理功能。

在分枝杆菌中，铁依赖性转录调节剂（IdeR）响应铁水平调节基因的转录。大部分在结核分枝杆菌，耻垢分枝杆菌和其他一些相关物种中研究了受IdeR调控的基因。晶体结构解决方案以及IdeR靶标的计算和实验鉴定的最新进展为IdeR的结构和功能提供了见识。在本文中，我们总结了有关IdeR及其目标的当前知识状态，以了解IdeR调节子的基本设计及其在分枝杆菌生理学中的作用。