Plasmodium falciparum parasites resistant to the combination sulfadoxine-pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter of concern because there are no other affordable drugs available. This article provides the evidence indicating that sulfadoxine-pyrimethamine resistance can be reversed in vitro and discusses how this information might be exploited to extend the therapeutic lifetime of sulfadoxine-pyrimethamine in vivo.

中文翻译：

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恶性疟原虫中叶酸摄取抑制的治疗潜力。

对磺胺多辛-乙胺嘧啶有抗药性的恶性疟原虫在非洲，特别是在东非蔓延。这是一个令人关注的问题，因为没有其他负担得起的药物。本文提供的证据表明，磺胺多辛-乙胺嘧啶的耐药性可以在体外逆转，并讨论了如何利用此信息来延长磺胺多辛-乙胺嘧啶的体内治疗寿命。