This case-control study was designed to examine the association between blood lead levels and high blood pressure in a restricted subpopulation, Saudi women who were 45-93-year old, during or after menopausal period and not occupationally exposed to lead. Blood lead levels were assessed in 100 women with hypertension and 85 control subjects. Lead concentrations were measured in the whole blood using flameless atomic absorption spectrophotometry. Blood pressure measurements were performed according to the World Health Organization recommendations. Results revealed that the mean blood lead levels for hypertensive were 47.52+/-39.26 and 45.59+/-28.55 microg/l for controls. Participants were classified according to the median of blood lead levels in order to compute odds ratios. After controlling a number of potential confounding variables, the multiple logistic regression analysis revealed that women with blood lead levels of > or = 38.6 microg/l were 5.27 times more likely to be hypertensive than those with blood lead levels of < 38.6 microg/l, but of borderline significance (p = 0.06). Although such observation might support the hypothesis that the depletion of lead from bones during menopause increases blood lead levels placing women at increased risk for high blood pressure, there is a need for further studies with larger number of subjects. A number of risk factors, which were suspected to influence blood lead levels, were also investigated. Use of Kohl, duration of its use, osteoporosis disease and intake of calcium supplements were significantly associated with blood lead levels.

中文翻译：

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在沙特女性中，铅是否被视为绝经期高血压的危险因素？

这项病例对照研究旨在研究限制亚人群中的铅含量与高血压之间的关系，这些人群为45-93岁的绝经期或绝经后且没有职业性接触铅的沙特妇女。在100名高血压妇女和85名对照受试者中评估了血铅水平。使用无焰原子吸收分光光度法测量全血中的铅浓度。根据世界卫生组织的建议进行血压测量。结果显示，对照组的平均血铅水平为47.52 +/- 39.26和45.59 +/- 28.55 microg / l。根据血铅水平的中位数对参与者进行分类，以计算比值比。在控制了许多潜在的混杂变量之后，多元logistic回归分析显示，血铅水平>或= 38.6 microg / l的女性比血铅水平<38.6 microg / l的女性高5.27倍，但具有临界意义（p = 0.06） 。尽管这种观察可能支持以下假设：更年期期间骨骼中铅的消耗会增加血铅水平，使妇女患高血压的风险增加，但仍需要对更多受试者进行进一步研究。还调查了许多可能影响血铅水平的危险因素。科尔的使用，使用时间，骨质疏松症和钙补充剂的摄入与血铅水平显着相关。6微克/升的高血压可能性是血铅水平<38.6微克/升的人的5.27倍，但具有临界意义（p = 0.06）。尽管这种观察可能支持以下假设：更年期期间骨骼中铅的消耗会增加血铅水平，使妇女患高血压的风险增加，但仍需要对更多受试者进行进一步研究。还调查了许多可能影响血铅水平的危险因素。科尔的使用，使用时间，骨质疏松症和钙补充剂的摄入与血铅水平显着相关。6微克/升的高血压可能性是血铅水平<38.6微克/升的人的5.27倍，但具有临界意义（p = 0.06）。尽管这种观察可能支持以下假设：更年期期间骨骼中铅的消耗会增加血铅水平，使妇女患高血压的风险增加，但仍需要对更多受试者进行进一步研究。还调查了许多可能影响血铅水平的危险因素。科尔的使用，使用时间，骨质疏松症和钙补充剂的摄入与血铅水平显着相关。尽管这种观察可能支持以下假设：更年期期间骨骼中铅的消耗会增加血铅水平，使妇女患高血压的风险增加，但仍需要对更多受试者进行进一步研究。还调查了许多可能影响血铅水平的危险因素。科尔的使用，使用时间，骨质疏松症和钙补充剂的摄入与血铅水平显着相关。尽管这种观察可能支持以下假设：更年期期间骨骼中铅的消耗会增加血铅水平，使妇女患高血压的风险增加，但仍需要对更多受试者进行进一步研究。还调查了许多可能影响血铅水平的危险因素。科尔的使用，使用时间，骨质疏松症和钙补充剂的摄入与血铅水平显着相关。