Esophageal cancer is the ninth most common malignancy in the world and the seventh leading cause of death in American men. Because symptoms are often intermittent and vague, patients typically present at an advanced stage, with limited survival. In operable patients, standard care includes surgery with or without adjuvant chemotherapy and radiotherapy; chemotherapy and radiotherapy is the standard care for inoperable disease. Docetaxel, a taxane that promotes polymerization of tubules and inhibits depolymerization of microtubules, has shown in vitro and in vivo antitumor effects on human gastric cell lines and gastric cancer xenografts. These antitumor effects have led to the evaluation of docetaxel as a single agent and in combination with other agents and modalities in patients with esophageal cancer. Results of relevant trials are reviewed herein.

中文翻译：

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多西他赛用于治疗食道癌。

食道癌是世界上第九大最常见的恶性肿瘤，也是美国男性第七大死亡原因。由于症状通常是间歇性和模糊的，因此患者通常出现在晚期，生存期有限。对于可手术患者，标准护理包括有或没有辅助化疗和放疗的手术；化学疗法和放射疗法是不可手术疾病的标准护理。多西他赛是一种紫杉烷，可促进肾小管的聚合并抑制微管的解聚，已显示出对人胃细胞系和胃癌异种移植物的体外和体内抗肿瘤作用。这些抗肿瘤作用已导致对多西他赛作为单一药物以及与其他药物和食道癌方式联合使用的评估。