Human growth factors are firmly established in treatment of cytopenias that are associated with cancer chemotherapy, and have been used successfully to reduce severe mucositis in patients receiving radiation therapy and chemotherapy in the setting of autologous bone marrow transplantation. The ability of growth factors that are involved in differentiation and proliferation of neural tissue cells to prevent or accelerate recovery from radiation injury currently is being evaluated in preclinical studies. Data from these studies indicate that brief therapeutic intervention with platelet-derived growth factor, insulin-like growth factor-1, vascular endothelial growth factor, and the combination of insulin-like growth factor-1 and basic fibroblast growth factor can prevent or delay radiation myelopathy after spinal cord irradiation. Additional investigation is required to define potentially clinically useful growth factor regimens in the clinic.

中文翻译：

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生长因子在减少放射治疗神经组织损伤中的潜在作用。

在与癌症化疗相关的血细胞减少症的治疗中，人类生长因子得到了牢固的确立，并已成功用于减轻自体骨髓移植中接受放射治疗和化疗的患者的严重粘膜炎。目前，临床前研究正在评估与神经组织细胞的分化和增殖有关的生长因子预防或加速放射损伤恢复的能力。这些研究的数据表明，对血小板源性生长因子，胰岛素样生长因子-1，血管内皮生长因子以及胰岛素样生长因子-1和碱性成纤维细胞生长因子的联合进行短暂的治疗干预可以预防或延迟放疗脊髓照射后发生脊髓病。