Non-small cell lung cancer continues to be a major oncologic problem, with approximately 3-month increase in median survival per decade since the 1970s. Thus, newer strategies are needed to improve outcomes in non-small cell lung cancer. New treatment strategies include optimizing and intensifying radiation therapy (RT) delivery, as well as improving systemic therapy with newly developed targeted agents. Three-dimensional treatment planning is a key technology for optimizing RT delivery. Additionally, improvements in radiation therapy will clearly require better target delineation and dose-intensification of RT. With newer, possibly less toxic agents such as the epidermal growth factor receptor inhibitors, RT and systemic therapy (with chemo- and/or targeted therapies) may be optimized in the concurrent setting, perhaps reserving more cytotoxic regimens either for the induction or maintenance settings.

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更积极的疗法是否能够改善局部晚期非小细胞肺癌的治疗：联合治疗？

非小细胞肺癌仍然是主要的肿瘤学问题，自1970年代以来，每十年的中位生存期增加了约3个月。因此，需要新的策略来改善非小细胞肺癌的预后。新的治疗策略包括优化和加强放射治疗（RT）的交付，以及使用新开发的靶向药物改善全身治疗。三维治疗计划是优化RT输送的关键技术。此外，放射治疗的改善显然需要更好的靶标描绘和RT剂量增强。使用更新的，可能毒性较小的药物（例如表皮生长因子受体抑制剂），RT和全身疗法（采用化学疗法和/或靶向疗法），可以在同时进行优化，