Valid interpretation of preclinical animal models in immunology-related clinical challenges is important to solve outstanding clinical needs. Given the overall complexity of the immune system and both species- and tissue-specific immune peculiarities, the selection and design of appropriate immune-relevant animal models is, however, not following a straightforward path. The topics in this issue of the ILAR Journal provide assessments of immune-relevant animal models used in oncology, hematopoietic-, CAR-T cell- and xenotransplantation, adjuvants and infectious diseases, and immune privileged inflammation that are providing key insights into unmet human clinical needs.

中文翻译：

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简介：免疫相关动物模型：机遇与挑战。

在免疫学相关的临床挑战中对临床前动物模型的有效解释对于解决突出的临床需求非常重要。考虑到免疫系统的总体复杂性以及物种和组织特异性的免疫特性，因此，选择和设计与免疫相关的合适动物模型并不是一条简单的道路。本期《 ILAR期刊》的主题提供了对肿瘤，造血，CAR-T细胞和异种移植，佐剂和传染性疾病以及免疫特权性炎症中使用的与免疫相关的动物模型的评估，这些模型为未得到满足的人类临床提供了重要见识需要。