Meningiomas are common intracranial tumors, and most exhibit optimal prognosis; however, some meningiomas still recur and even develop malignant transformation in the following years, regardless of initial pathological grade. During these years, autophagy raises its significance in tumorigenesis and tumor suppression, both important for tumor development. The aim of this study was to elucidate the relationship between two autophagy markers, LC3B and beclin 1, with clinical and pathological parameters in patients with meningiomas. A total of 77 thin-sectioned slides, retrospectively collected from meningioma patients, were analyzed and correlated with clinicopathological parameters. We found that expression of beclin 1 rather than LC3B correlated to better prognosis, lower pathological grade, and longer survival. Furthermore, intensity of beclin 1 was also found to be significantly related to the pathological grade. These findings indicated that beclin 1 as a protective factor predicts better prognosis and plays the role of tumor suppression in meningiomas.

中文翻译：

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Beclin 1在人脑膜瘤中的更高表达与更好的临床结果和病理分级有关。

脑膜瘤是常见的颅内肿瘤，大多数预后最佳。然而，无论最初的病理分级如何，在随后的几年中，一些脑膜瘤仍会复发，甚至发展成恶性转化。在这些年中，自噬在肿瘤发生和抑制肿瘤中起着重要的作用，这对肿瘤的发展都很重要。这项研究的目的是阐明脑膜瘤患者中两种自噬标记物LC3B和Beclin 1与临床和病理参数之间的关系。回顾性分析了从脑膜瘤患者中收集的总共77张薄切片玻片，并将其与临床病理参数相关联。我们发现beclin 1而不是LC3B​​的表达与更好的预后，较低的病理分级和更长的生存期相关。此外，还发现Beclin 1的强度与病理分级显着相关。这些发现表明，beclin 1作为一种保护因子可以预测更好的预后，并在脑膜瘤中发挥肿瘤抑制作用。