Reptile contact can result in zoonotic non‐typhoidal salmonellosis. In April 2018, Oregon Public Health Division contacted CDC about a cluster of four Salmonella serovar Fluntern (SF) illnesses in four states (OR, CA, IA, NY); patients reported contact with geckos, a popular reptile pet. PulseNet, the national molecular subtyping network of food‐borne disease surveillance, subsequently identified additional SF clinical isolates. Twelve cases in 11 states were identified; median age was 5 years (range: <1–58 years). Three patients were hospitalized; no deaths were reported. Of those with exposure information (n = 10), all reported reptile exposure; 9 (90%) specified contact with leopard geckos. No common source of geckos was identified from reported purchase locations. Los Angeles County (LAC) health officials isolated SF from one patient's leopard gecko. Five reptile/gecko isolates were identified from the USDA National Veterinary Services Laboratories (NVSL) from 2015 to 2018. Five countries responded to an Epidemic Intelligence Information System post by PulseNet; reptile isolate sequence data were received from Czech Republic. A clinical case from England was identified through the National Center for Biotechnology Information pathogen detection pipeline; the patient did not report contact with leopard geckos. Whole genome sequencing analysis revealed substantial genetic diversity between clinical and animal isolates; however, gecko and clinical isolates from LAC were highly related (1 allele difference). This investigation linking SF illnesses to leopard geckos highlights an important public health risk from pets. A better understanding of how geckos are distributed by the pet industry in the United States could improve traceability to points of origin and mitigate Salmonella transmission at gecko breeders. Earlier NVSL reports of SF isolates from geckos suggest the risk of human SF infection from geckos is not new. This investigation demonstrates a need to educate gecko breeders, retailers and gecko owners about the continued Salmonella infection risk from pet geckos.

中文翻译：

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美国与豹纹壁虎有关的沙门氏菌绒毛病调查，2018年。

爬行动物接触可导致人畜共患的非伤寒沙门氏菌病。2018年4月，俄勒冈州公共卫生部门就四个州（俄勒冈州，加利福尼亚州，爱荷华州，纽约州）的四种沙门氏菌绒毛（SF）疾病集群与CDC联系。患者报告与壁虎接触，壁虎是一种受欢迎的爬行动物。食源性疾病监测的国家分子子类型网络PulseNet随后确定了其他SF临床分离株。确定了11个州的12个案件；中位年龄为5岁（范围：<1–58岁）。三名患者住院；没有死亡的报道。那些有接触信息的人（n = 10），所有报告的爬行动物接触；9（90％）与豹纹壁虎有指定接触。从报告的购买地点未发现壁虎的常见来源。洛杉矶县（LAC）卫生官员从一名患者的豹纹壁虎中分离出SF。从2015年至2018年，美国农业部国家兽医服务实验室（NVSL）确定了5种爬行动物/壁虎分离株。5个国家对PulseNet的流行病情报系统作出了回应；爬行动物分离物序列数据来自捷克共和国。通过国家生物技术信息病原体检测管道确定了英格兰的临床病例；该患者未报告有豹纹壁虎的接触。全基因组测序分析表明，临床分离株和动物分离株之间存在大量遗传多样性。然而，壁虎和来自LAC的临床分离株高度相关（1个等位基因差异）。这项将科幻疾病与豹纹壁虎联系起来的调查突显了宠物的重要公共健康风险。更好地了解美国宠物业如何分配壁虎可以改善对起源地的可追溯性并减轻壁虎繁殖者的沙门氏菌传播。NVSL较早的关于从壁虎中分离出SF的报道表明，壁虎对人类SF感染的风险并不新鲜。这项调查表明，有必要对壁虎育种者，零售商和壁虎主人进行培训，以了解宠物壁虎持续感染沙门氏菌的风险。