Demonstration that immature CD4 + 8+ thymocytes contain T cell precursors that are subjected to positive and negative selection was the major step towards understanding how the adaptive immune system acquires the ability to distinguish foreign or abnormal (mutated or infected) self-cells from normal (healthy) cells. In the present review, the roles of TCR, CD4, CD8, and MHC molecules in intrathymic selection and some of the crucial experiments that contributed to the solution of the great immunological puzzle of self/nonself discrimination are described in an historical perspective. Recently, these experiments were highlighted by the immunological community by awarding the 2016 Novartis Prize for Immunology to Philippa Marrack, John Kappler, and Harald von Boehmer.

中文翻译：

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免疫系统如何学会区分善恶？ T 细胞中枢耐受和正选择的第一个明确研究。


证明未成熟的 CD4 + 8+ 胸腺细胞含有受到正向和负向选择的 T 细胞前体，这是理解适应性免疫系统如何获得区分外来或异常（突变或感染）自体细胞与正常自体细胞的能力的重要一步。健康）细胞。在本综述中，从历史角度描述了 TCR、CD4、CD8 和 MHC 分子在胸腺内选择中的作用，以及有助于解决自我/非自我歧视这一免疫学难题的一些关键实验。最近，这些实验受到免疫学界的高度重视，将 2016 年诺华免疫学奖授予 Philippa Marrack、John Kappler 和 Harald von Boehmer。