Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice.,Emerging Microbes & Infections

当前位置： X-MOL 学术 › Emerg. Microbes Infect. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice.
Emerging Microbes & Infections ( IF 8.4 ) Pub Date : 2019-07-04 , DOI: 10.1080/22221751.2019.1635873
Wenfei Zhu _{1,

2} , Zhaomin Feng _{1,

2} , Yongkun Chen ₃ , Lei Yang _{1,

2} , Jia Liu _{1,

2} , Xiyan Li _{1,

2} , Suli Liu ₃ , Lijuan Zhou _{1,

2} , Hejiang Wei _{1,

2} , Rongbao Gao _{1,

2} , Dayan Wang _{1,

2} , Yuelong Shu _{1,

2,

3}

Affiliation

It has recently been proposed that the Eurasian avian-like H1N1 (EA H1N1) swine influenza virus (SIV) is one of the most likely zoonotic viruses to cause the next influenza pandemic. Two main genotypes EA H1N1 viruses have been recognized to be infected humans in China. Our study finds that one of the genotypes JS1-like viruses are avirulent in mice. However, the other are HuN-like viruses and are virulent in mice. The molecular mechanism underlying this difference shows that the NP gene determines the virulence of the EA H1N1 viruses in mice. In addition, a single substitution, Q357K, in the NP protein of the EA H1N1 viruses alters the virulence phenotype. This substitution is a typical human signature marker, which is prevalent in human viruses but rarely detected in avian influenza viruses. The NP-Q357K substitution is readily to be occurred when avian influenza viruses circulate in pigs, and may facilitate their infection of humans and allow viruses also carrying NP-357K to circulate in humans. Our study demonstrates that the substitution Q357K in the NP protein plays a key role in the virulence phenotype of EA H1N1 SIVs, and provides important information for evaluating the pandemic risk of field influenza strains.

更新日期：2019-11-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11