Alzheimer's disease (AD) is one of the most common types of dementia among the elderly. Previous studies had revealed that the dysregulation of lncRNAs played important roles in human diseases, including AD. However, there is still a lack of comprehensive analysis of differently expressed long non-coding RNAs (lncRNAs) in different distinct regions related to AD. In present study, we identified a total of 678, 593, 941, 1445, 1179, 466 differently expressed lncRNAs that were found in entorhinal cortex (EC), middle temporal gyrus(MTG), hippocampus (HIP), superior frontal gyrus (SFG), posterior cingulate (PC), cortex and primary visual cortex (VCX) AD samples, respectively. Furthermore, we constructed lncRNA-mRNA co-expression networks in AD to explore the potential roles of these lncRNAs. Differentially expressed (DE) lncRNAs were involved in regulating metabolic process, respiratory electron transport chain and ATP metabolic process showed by GO analysis. Interestingly, KEGG analysis revealed these lncRNAs were associated with neurodegenerative disorders such as Alzheimer's disease, Huntington's disease and Parkinson's disease. Four lncRNAs (LOC100507557, LOC101929787, NEAT1, and JAZF1-AS1) were identified as key lncRNAs in AD progression and dysregulated in different distinct regions related to AD. Our study has uncovered several key lncRNAs in AD, which would give novel underlying therapeutic and prognostic targets for AD.

中文翻译：

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共表达网络分析揭示了lncRNA在阿尔茨海默氏病中的潜在调控作用。

阿尔茨海默氏病（AD）是老年人中最常见的痴呆类型之一。先前的研究表明，lncRNA的失调在包括AD在内的人类疾病中起着重要作用。但是，仍然缺乏对与AD相关的不同区域中不同表达的长非编码RNA（lncRNA）的全面分析。在本研究中，我们鉴定出共678、593、941、1445、1179、466种不同表达的lncRNA，分别在内嗅皮层（EC），中颞回（MTG），海马（HIP），上额回（SFG）中发现），后扣带回（PC），皮质和原发性视觉皮层（VCX）AD样本。此外，我们在AD中构建了lncRNA-mRNA共表达网络，以探索这些lncRNA的潜在作用。GO分析显示，差异表达（DE）lncRNA参与调节代谢过程，呼吸电子转运链和ATP代谢过程。有趣的是，KEGG分析显示这些lncRNA与神经退行性疾病（例如阿尔茨海默氏病，亨廷顿氏病和帕金森氏病）有关。四个lncRNA（LOC100507557，LOC101929787，NEAT1和JAZF1-AS1）被确定为AD进展中的关键lncRNA，并且在与AD相关的不同区域中表达异常。我们的研究发现了AD中的几个关键lncRNA，它们将为AD提供新的潜在治疗和预后靶标。KEGG分析显示这些lncRNA与神经退行性疾病如阿尔茨海默氏病，亨廷顿氏病和帕金森氏病有关。四个lncRNA（LOC100507557，LOC101929787，NEAT1和JAZF1-AS1）被确定为AD进展中的关键lncRNA，并且在与AD相关的不同区域中表达异常。我们的研究发现了AD中的几个关键lncRNA，它们将为AD提供新的潜在治疗和预后靶标。KEGG分析显示这些lncRNA与神经退行性疾病如阿尔茨海默氏病，亨廷顿氏病和帕金森氏病有关。四个lncRNA（LOC100507557，LOC101929787，NEAT1和JAZF1-AS1）被确定为AD进展中的关键lncRNA，并且在与AD相关的不同区域中表达异常。我们的研究发现了AD中的几个关键lncRNA，它们将为AD提供新的潜在治疗和预后靶标。