Central nervous system (CNS) metastasis is a significant problem for many patients with non-small cell lung cancer (NSCLC). The earlier data reported a high incidence of CNS metastasis in patients with locally advanced NSCLC who were treated with radiotherapy alone. However, poor control of both thoracic and extracranial systemic disease dominated the results of the early trials. The risk for CNS metastasis as the first site of failure remains a significant concern for patients who have completed modern combined modality therapy. With improvements in the treatment of thoracic and systemic disease, there is renewed interest in prophylactic cranial irradiation (PCI). The results from the Radiation Therapy Oncology Group (RTOG) trial of PCI to prevent CNS relapse in patients with locally advanced NSCLC are anticipated.

中文翻译：

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局部晚期非小细胞肺癌患者的联合颅骨预防性放射治疗。

对于许多非小细胞肺癌（NSCLC）患者，中枢神经系统（CNS）转移是一个重大问题。早期的数据报道，仅接受放射治疗的局部晚期NSCLC患者中枢神经系统转移的发生率很高。然而，对胸部和颅外系统性疾病的控制不力主导了早期试验的结果。作为失败的第一个部位，CNS转移的风险仍然是已完成现代联合治疗的患者的重大关切。随着胸和全身性疾病治疗的改善，人们对预防性颅脑照射（PCI）有了新的兴趣。预期PCI放射治疗肿瘤小组（RTOG）试验可预防局部晚期NSCLC患者中枢神经系统复发的结果。