Follicular dendritic cells (FDCs) play central roles in the B cell survival, proliferation, and differentiation into memory cells. Here, we show that TuJ1 (class III beta-tubulin) is expressed strongly in FDCs of human lymphoid tissue. TuJ1 has been a marker of neurons in the central and peripheral nervous systems from the early stage of neural differentiation. FDCs expressed TuJ1 protein diffusely in both light and dark zones of germinal centers in all human lymphoid tissues. In contrast, CD21 expression was relatively concentrated to the light zone, suggesting that TuJ1 was a marker for FDCs with broader spectrum than CD21. In addition to the germinal center, there were single TuJ1-expressing cells scattered in the mantle zone, blurring the border of the FDC network. In human tonsils, single scattered TuJ1-positive cells were also present in the crypt epithelium, suggesting a dynamic redistribution of FDCs among the antigen-rich epithelium, mantle zone, and germinal center. Such migration of FDCs could reflect a way of direct transport of various antigens carried on their surface to the germinal center, and a basis for the polarity of lymphoid follicles toward the epithelium in mucosa-associated lymphoid tissues. HK cells, cultured FDCs, also expressed TuJ1. The expression of TuJ1 by FDCs suggests that they may share certain biological characteristics of the neural system.

中文翻译：

---

TuJ1（III类β-微管蛋白）表达表明淋巴组织中滤泡树突状细胞的动态重新分布。

滤泡树突状细胞（FDC）在B细胞存活，增殖和分化成记忆细胞中起着核心作用。在这里，我们显示TuJ1（III类β-微管蛋白）在人淋巴组织的FDC中强烈表达。从神经分化的早期开始，TuJ1已经成为中枢和周围神经系统中神经元的标志物。FDC在所有人类淋巴组织的生发中心的明暗区域均弥散表达TuJ1蛋白。相反，CD21的表达相对集中在亮区，这表明TuJ1是FDC的标志，其光谱比CD21宽。除了生发中心外，在地幔区还散布着单个表达TuJ1的细胞，从而模糊了FDC网络的边界。在人类扁桃体中 隐窝上皮细胞中还存在单个散布的TuJ1阳性细胞，这表明FDC在富含抗原的上皮细胞，地幔区和生发中心之间动态重新分布。FDCs的这种迁移可能反映了将其表面上携带的各种抗原直接转运至生发中心的方式，并且是与粘膜相关的淋巴组织中淋巴滤泡朝向上皮的极性的基础。HK细胞，培养的FDC，也表达TuJ1。FDCs表达TuJ1表明它们可能具有神经系统的某些生物学特性。FDCs的这种迁移可能反映了将其表面上携带的各种抗原直接转运至生发中心的方式，并且是与粘膜相关的淋巴组织中淋巴滤泡朝向上皮的极性的基础。HK细胞，培养的FDC，也表达TuJ1。FDCs表达TuJ1表明它们可能具有神经系统的某些生物学特性。FDCs的这种迁移可能反映了将其表面上携带的各种抗原直接转运至生发中心的方式，并且是与粘膜相关的淋巴组织中淋巴滤泡朝向上皮的极性的基础。HK细胞，培养的FDC，也表达TuJ1。FDCs表达TuJ1表明它们可能具有神经系统的某些生物学特性。