Cartilage repair and regeneration by stem cell-based tissue engineering could be of enormous therapeutic and economic potential benefit for an aging population. However, to use stem cells effectively, their natural environment must be understood in order to expand them in vitro without compromising their multilineage potential and their specific differentiation program. Collaboration between diverse academic disciplines and between research and regulatory government agencies and industry is crucial before cell-based cartilage tissue engineering can achieve its full therapeutic potential.

中文翻译：

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基于间充质干细胞的软骨组织工程：细胞、支架和生物学

通过基于干细胞的组织工程进行软骨修复和再生可能对老龄化人口具有巨大的治疗和经济潜力。然而，为了有效地使用干细胞，必须了解它们的自然环境，以便在不影响其多向潜能和特定分化程序的情况下在体外扩增它们。在基于细胞的软骨组织工程实现其全部治疗潜力之前，不同学科之间以及研究和监管政府机构与行业之间的合作至关重要。