Keratinocyte growth factor (KGF) is a potent and specific mitogen for different types of epithelial cells, and it can protect these cells from various insults. Due to these properties, it is of particular importance for the repair of injured epithelial tissues, and it is currently therapeutically explored for the treatment of radiation- and chemotherapy-induced mucosal epithelial damage in cancer patients. In this review we summarize the current knowledge on the role of KGF in tissue repair and cytoprotection, and we report on its mechanisms of action in keratinocytes.

中文翻译：

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角质形成细胞生长因子：对角质形成细胞的作用及其作用机制。

角质形成细胞生长因子（KGF）是一种有效的特异促分裂原，适用于不同类型的上皮细胞，它可以保护这些细胞免受各种损伤。由于这些性质，它对于修复受损的上皮组织特别重要，并且目前在治疗上已被探索用于治疗癌症患者的放射线和化学疗法引起的粘膜上皮损伤。在这篇综述中，我们总结了有关KGF在组织修复和细胞保护中作用的最新知识，并报道了其在角质形成细胞中的作用机理。