Depression represents a major source of disability among individuals who have suffered a traumatic brain injury (TBI), with estimates of prevalence in this population ranging over 50%. In comparison with other sequelae of TBI, depression is often poorly conceptualized and treated among acute care and rehabilitation professionals. One reason for this is the lack of clear etiological models for the development of depression following TBI. This paper argues that post-TBI depression actually represents a heterogeneous category, with multiple etiologic pathways and clinical implications. The literature in this area is reviewed, with an emphasis on an appreciation of the diversity within this clinical population. Conclusions focus on suggestions for differential diagnosis and treatment options.

中文翻译：

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脑外伤后的抑郁症：临床异质性证据综述。

抑郁症是遭受外伤性脑损伤（TBI）的个体中残疾的主要来源，据估计该人群的患病率超过50％。与TBI的其他后遗症相比，急性护理和康复专业人员通常对抑郁症的概念了解不多，并且无法对其进行治疗。原因之一是缺乏明确的病因学模型，以了解TBI后抑郁症的发展。本文认为，TBI后抑郁症实际上代表了一个异质性类别，具有多种病因途径和临床意义。回顾了该领域的文献，重点是对该临床人群中多样性的认识。结论集中于鉴别诊断和治疗选择的建议。