A strain of Penicillium corylophilum isolated from Brazilian soil sample was submitted to different culture conditions to investigate the production of secondary metabolites with antimicrobial activity. The largest number of conidia was obtained after 5 days of incubation in oat medium and the highest level of antimicrobial activity was produced when the fungus culture was developed in the Czapek medium. The activity against Staphylococcus aureus was found only in the chloroform extract from Czapek culture broth, which also showed activity against Micrococcus luteus. Fumiquinozoline F was isolated from the active chloroform extract by using chromatographic methods. The minimal inhibitory concentration (MIC) values for M. luteus and S. aureus were 99 microg/ mL and 137microg/mL, respectively.

中文翻译：

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耐青霉青霉Dierckx的抗菌活性。

从巴西土壤样品中分离出的青霉青霉菌菌株用于不同的培养条件，以研究具有抗菌活性的次生代谢产物的产生。在燕麦培养基中孵育5天后，获得的分生孢子数量最多，而在Czapek培养基中培养真菌培养物时，则产生了最高水平的抗菌活性。仅在来自Czapek培养液的氯仿提取物中发现了针对金黄色葡萄球菌的活性，其还显示了针对黄褐微球菌的活性。通过色谱法从活性氯仿提取物中分离出氟喹唑啉F。黄褐线虫和金黄色葡萄球菌的最小抑菌浓度（MIC）值分别为99 microg / mL和137microg / mL。