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REM sleep behavior disorder: clinical and physiopathological findings.
Sleep Medicine Reviews ( IF 10.5 ) Pub Date : 2004-08-18 , DOI: 10.1016/s1087-0792(97)90006-x
E Sforza 1 , J Krieger , C Petiau
Affiliation  

Abnormalities of REM sleep i.e. absence of atonia and abnormal motor control which are described in patients with REM sleep behavior disorder, have induced clinical and physiopathological interest. Initial hypothesis of a simple dysfunction of REM sleep generators has not been confirmed. The prevalence in older subjects and in patients with parkinsonian syndromes suggest that the appearance of the parasomnia is related to alteration in the neurons of pontine area i.e. nucleus peduncolopontine, in which there is an integration of sleep-wake mechanisms and locomotor systems. Controversy surrounds the specificity of absence of atonia in the diagnosis of the parasomnia. Since this polygraphic finding may be present in subjects without any sleep complaint and in patients with initial neurological impairment, diagnosis of the sleep disorders might be allowed only when the polygraphic characteristic of persistent tonus and complex motor behavior are recorded.

中文翻译:

REM睡眠行为障碍:临床和生理病理学发现。

REM睡眠行为异常患者描述的REM睡眠异常,即无失语和运动控制异常,引起了临床和生理病理学兴趣。尚未证实REM睡眠产生器的简单功能障碍的最初假设。老年受试者和帕金森综合症患者的患病率表明,失眠症的出现与桥脑区域神经元的改变有关,即peduncolopontine核,其中睡眠-唤醒机制和运动系统的整合。围绕失语症的诊断是否存在失眠的争议一直存在争议。由于这项多态性检查结果可能出现在没有任何睡眠不适的受试者以及最初的神经功能缺损的患者中,
更新日期:2019-11-01
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