Many polymorphisms have been described for the genes encoding the beta 1, beta 2, and alpha 2c-adrenoceptors that result in altered signaling and/or regulatory properties of the receptors. Several studies have investigated whether these properties affect the cardiovascular function of these receptors in mice or in humans, but have yielded mixed results. Some studies suggest that adrenoceptor polymorphisms might alter the risk for heart failure and the response to treatment with beta-blockers. However, the complex haplotypes resulting from combinations of individual polymorphisms have not yet been investigated, and firm conclusions or recommendations cannot be made because of the low patient numbers in each of the study programs.

中文翻译：

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β-肾上腺素受体多态性与心力衰竭。

已经描述了编码β1，β2和α2c-肾上腺素能受体基因的许多多态性，这些基因导致受体的信号传导和/或调节特性发生改变。几项研究调查了这些性质是否会影响这些受体在小鼠或人类中的心血管功能，但得出的结果却不尽相同。一些研究表明，肾上腺素受体多态性可能会改变心力衰竭的风险以及对β受体阻滞剂治疗的反应。但是，尚未研究由单个多态性的组合产生的复杂单倍型，并且由于每个研究程序中的患者人数较少，因此无法做出确定的结论或建议。