Network architecture and regulatory logic in neural crest development.,WIREs Mechanisms of Disease

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Network architecture and regulatory logic in neural crest development.
WIREs Mechanisms of Disease ( IF 4.6 ) Pub Date : 2019-11-08 , DOI: 10.1002/wsbm.1468
Austin S Hovland ₁ , Megan Rothstein ₁ , Marcos Simoes-Costa ₁

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The neural crest is an ectodermal cell population that gives rise to over 30 cell types during vertebrate embryogenesis. These stem cells are formed at the border of the developing central nervous system and undergo extensive migration before differentiating into components of multiple tissues and organs. Neural crest formation and differentiation is a multistep process, as these cells transition through sequential regulatory states before adopting their adult phenotype. Such changes are governed by a complex gene regulatory network (GRN) that integrates environmental and cell‐intrinsic inputs to regulate cell identity. Studies of neural crest cells in a variety of vertebrate models have elucidated the function and regulation of dozens of the molecular players that are part of this network. The neural crest GRN has served as a platform to explore the molecular control of multipotency, cell differentiation, and the evolution of vertebrates. In this review, we employ this genetic program as a stepping‐stone to explore the architecture and the regulatory principles of developmental GRNs. We also discuss how modern genomic approaches can further expand our understanding of genetic networks in this system and others.

中文翻译：

神经c开发中的网络架构和调节逻辑。

神经rest是一种外胚层细胞群，在脊椎动物胚胎发生过程中会产生30多种细胞类型。这些干细胞在发育中的中枢神经系统的边界处形成，并经历广泛的迁移，然后分化为多种组织和器官的成分。神经c的形成和分化是一个多步骤的过程，因为这些细胞在采用其成年表型之前会通过连续的调节状态转变。此类变化由复杂的基因调节网络（GRN）控制，该网络整合了环境和细胞内在输入以调节细胞身份。对各种脊椎动物模型中神经c细胞的研究阐明了作为该网络一部分的数十种分子分子的功能和调控。神经c GRN已成为探索多能性，细胞分化和脊椎动物进化的分子控制平台。在本综述中，我们将这种遗传程序作为探索发展型GRN的体系结构和调控原理的垫脚石。我们还将讨论现代基因组方法如何进一步扩展我们对该系统及其他系统中遗传网络的理解。

更新日期：2019-11-08

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