Among the methods used for the treatment of cancer, chemotherapy is widely used, and it is by far one of the most unpleasant procedures given to a patient because of its severe side effects; while being necessary. One of the major problems in cancer chemotherapy is the limited selectivity of most of the drugs in current clinical use. Following administration, the active agent is distributed over the entire body and reaches not only the target cells or tissues but also interacts with healthy cells. In an attempt to overcome the side effects of anticancer drugs, the modification of the anticancer bioactive compounds has been a topic of active research for years. Numerous delivery systems such as drugcontaining liposomes, microencapsulation, nanoparticles, and water-soluble polymers have been used for the delivery of bioactive compounds to the site of action. Water-soluble polymeric conjugates and co-conjugates have remained the most outstanding delivery technique. This review will discuss the development of polymeric conjugates and co-conjugates of ferrocene in cancer research.

中文翻译：

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癌症研究中含有有机铁基化合物的大分子前药：综述。

在用于治疗癌症的方法中，化学疗法被广泛使用，由于其严重的副作用，它是迄今为止给患者带来的最不愉快的治疗方法之一。同时是必要的。癌症化学疗法的主要问题之一是当前临床使用中大多数药物的选择性有限。给药后，活性剂分布在整个身体上，不仅到达靶细胞或组织，而且还与健康细胞相互作用。为了克服抗癌药的副作用，多年来抗癌生物活性化合物的修饰一直是积极研究的主题。多种递送系统，例如含药脂质体，微囊化，纳米颗粒，水溶性聚合物和水溶性聚合物已用于将生物活性化合物递送至作用部位。水溶性聚合物结合物和共结合物仍然是最杰出的递送技术。这篇综述将讨论癌症研究中二茂铁的聚合共轭物和共轭物的开发。