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The Functional Significance of Endocrine-immune Interactions in Health and Disease.
Current Protein & Peptide Science ( IF 1.9 ) Pub Date : 2019-11-05 , DOI: 10.2174/1389203720666191106113435
Sridhar Muthusami 1 , Balasubramanian Vidya 1 , Esaki M Shankar 2 , Jamuna Vadivelu 3 , Ilangovan Ramachandran 4 , Jone A Stanley 5 , Nagarajan Selvamurugan 6
Affiliation  

Hormones are known to influence various body systems that include skeletal, cardiac, digestive, excretory, and immune systems. Emerging investigations suggest the key role played by secretions of endocrine glands in immune cell differentiation, proliferation, activation, and memory attributes of the immune system. The link between steroid hormones such as glucocorticoids and inflammation is widely known. However, the role of peptide hormones and amino acid derivatives such as growth and thyroid hormones, prolactin, dopamine, and thymopoietin in regulating the functioning of the immune system remains unclear. Here, we reviewed the findings pertinent to the functional role of hormone-immune interactions in health and disease and proposed perspective directions for translational research in the field.

中文翻译:

内分泌免疫相互作用在健康和疾病中的功能意义。

已知激素会影响包括骨骼,心脏,消化,排泄和免疫系统在内的各种身体系统。新兴的研究表明,内分泌腺分泌物在免疫系统的免疫细胞分化,增殖,活化和记忆特性中起着关键作用。诸如糖皮质激素的类固醇激素与炎症之间的联系是众所周知的。但是,尚不清楚肽激素和氨基酸衍生物(例如生长激素和甲状腺激素,催乳素,多巴胺和胸腺生成素)在调节免疫系统功能中的作用。在这里,我们审查了有关激素-免疫相互作用在健康和疾病中的功能作用的发现,并为该领域的转化研究提出了展望方向。
更新日期:2019-11-01
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