The failure to date of all disease modifying therapies for Alzheimer's disease and related dementias requires a serious rethinking of the field's approach to therapeutic interventions. This begins with the acknowledgement that the great majority of sporadic neurodegenerative dementias are the result of more than one toxic protein/species. While there are challenges to the initiation of clinical trials targeting more than one mechanism, there is an urgent need for a paradigm shift where a pleotropic and personalized approach is implemented to address the devastating personal and societal consequences of neurodegenerative dementias.

中文翻译：

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阿尔茨海默氏病和相关痴呆的联合疗法。

迄今为止，针对阿尔茨海默氏病和相关痴呆症的所有疾病改良疗法的失败都需要认真思考该领域的治疗干预方法。首先要认识到，绝大多数散发性神经退行性痴呆是由一种以上有毒蛋白质/物种引起的。尽管针对不止一种机制的临床试验的启动面临挑战，但迫切需要一种范式转变，在这种转变中，应采用多效性和个性化的方法来解决神经退行性痴呆的毁灭性的个人和社会后果。