Intraductal carcinomas (IDCs) are rare, not well-characterized salivary gland tumors. A systematic literature review of pure IDCs (without stromal invasion) of low-grade (LG-IDCs) or high-grade (HG-IDCs) was performed: IDCs were classified using the apocrine (AR+/S100-) vs intercalated (S100+/AR-) classification. Eighty-two LG-IDCs and 11 HG-IDCs were identified (84% parotid; 11% oral; 3% submandibular; 1% lacrimal; and 1% unknown). Out of 11 HG-IDCs, 2 HG-IDCs (18%) recurred as HG-IDC or invasive carcinoma. IDCs were classified as follows: intercalated (30%); mixed apocrine and intercalated (27%); apocrine (11%); oncocytic (6%); intercalated with focal oncocytic features (1%); and unclassifiable (25%). Double AR/S100 expressors (4%) or discrepancies between morphology and immunophenotype (9%) were found. Apocrine features and necrosis were more frequent in HG-IDCs (55%; 45%). Pleomorphism favored HG-IDCs (especially when combined with >10 mitoses/10 HPFs and/or Ki67 index >10%), being associated with apocrine areas at least in 3 HG-IDCs (27%). IDCs were typically mammaglobin+/ER-/PR-/DOG1-. No immunomarker clearly distinguished HG-IDCs from LG-IDCs. About 57% IDCs (16 LG-IDCs, 1 HG-IDC) showed RET rearrangements, including NCOA4-RET (eight intercalated and two unclassifiable IDCs) and TRIM27-RET fusions (two mixed IDCs). No ETV6, ALK-1, ROS, NTRK3, MAML2, MAML3, or PLAG1 rearrangements were identified. Complete excision and total sampling should exclude invasive areas.

中文翻译：

---

唾液腺导管内癌：93例已发表病例的系统回顾和分类。

导管内癌（IDC）是罕见的，不是唾液腺肿瘤的特征。对低级（LG-IDC）或高级（HG-IDC）的纯IDC（无基质浸润）进行了系统的文献综述：IDC的分类采用主教（AR + / S100-）与插层（S100 + / AR-）分类。鉴定出八十二个LG-IDC和11个HG-IDC（腮腺为84％；口腔为11％；颌下为3％；泪腺为1％；未知为1％）。在11个HG-IDC中，有2个HG-IDC（18％）复发为HG-IDC或浸润性癌。IDC的分类如下：插层（30％）；混合主教和插层（27％）; 顶泌素（11％）; 胞浆菌（6％）; 插入有局灶性胞浆特征（1％）；且无法分类（25％）。发现双重AR / S100表达子（4％）或形态与免疫表型之间的差异（9％）。在HG-IDC中，主分泌特征和坏死更为常见（55％； 45％）。多态性有利于HG-IDC（特别是与> 10个有丝分裂/ 10 HPF和/或Ki67指数> 10％结合使用时），至少在3个HG-IDC（27％）中与主教区域相关。IDC通常是乳球蛋白+ / ER- / PR- / DOG1-。没有免疫标记物能将HG-IDC与LG-IDC区分开。约57％的IDC（16个LG-IDC，1个HG-IDC）显示出RET重排，包括NCOA4-RET（8个插值和两个无法分类的IDC）和TRIM27-RET融合（两个混合IDC）。未识别到ETV6，ALK-1，ROS，NTRK3，MAML2，MAML3或PLAG1重排。完整切除和总采样应排除侵入区域。至少在3个HG-IDC中与教区相关（27％）。IDC通常是乳球蛋白+ / ER- / PR- / DOG1-。没有免疫标记物能将HG-IDC与LG-IDC区分开。约57％的IDC（16个LG-IDC，1个HG-IDC）显示出RET重排，包括NCOA4-RET（8个插值和两个无法分类的IDC）和TRIM27-RET融合（两个混合IDC）。未识别到ETV6，ALK-1，ROS，NTRK3，MAML2，MAML3或PLAG1重排。完整切除和总采样应排除侵入区域。至少在3个HG-IDC中与教区相关（27％）。IDC通常是乳球蛋白+ / ER- / PR- / DOG1-。没有免疫标记物能将HG-IDC与LG-IDC区分开。约57％的IDC（16个LG-IDC，1个HG-IDC）显示出RET重排，包括NCOA4-RET（8个插值和两个无法分类的IDC）和TRIM27-RET融合（两个混合IDC）。未识别到ETV6，ALK-1，ROS，NTRK3，MAML2，MAML3或PLAG1重排。完整切除和总采样应排除侵入区域。或PLAG1重排被识别。完整切除和总采样应排除侵入区域。或PLAG1重排被识别。完整切除和总采样应排除侵入区域。