System xc- (Sxc -) has emerged as a new biological target for PET studies to detect oxidative and excitotoxic stress. Notably, applications have, thus far, been limited to tumour imaging although Sxc- ) may play a major role in neurodegeneration. The synthesis procedures of tosylate precursor and its translation to Sxc - PET tracer 5[18F]fluoro-L-amino suberate by manual and automated radiosyntheses are described. A brain-PET study has been conducted to evaluate the tracer uptake into brain in healthy mice.

中文翻译：

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使用 5-[18 F]氟-L-氨基辛二酸酯的合成、放射合成和正电子发射断层扫描神经成像


xc- (Sxc-) 系统已成为 PET 研究检测氧化和兴奋性毒性应激的新生物靶标。值得注意的是，尽管 Sxc-) 可能在神经退行性变中发挥重要作用，但迄今为止，其应用仅限于肿瘤成像。描述了甲苯磺酸盐前体的合成程序及其通过手动和自动放射合成转化为 Sxc - PET 示踪剂 5[18F]氟-L-氨基辛二酸酯。已经进行了一项脑 PET 研究来评估健康小鼠大脑中示踪剂的吸收情况。