Although several physiological effects of Chrysanthemum indicum Linné (CL) have been researched, the specific effect and molecular mechanism of CL as a functional food material for skin health remain still unknown. Here, it was observed that the α-MSH and IBMX-initiated B16F10 melanogenesis was suppressed by the CL water extract (CLE) treatment. The CLE treatment also increased the mRNA expression levels of pro-collagen1α2, collagen1α2, and fibronectin via exerting the TGF-β/JNK signaling pathway. Together, the beneficial role of CLE in skin health was demonstrated through the downregulation of melanogenesis and enhancement of skin fibril-related genes. It was also revealed that the function of CLE is mediated with the activation of the TGF-β/JNK signaling pathway. These results may provide evidences for the development of functional foods using CLE for maintaining healthy skin.

中文翻译：

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菊花提取物通过调节TGF-β/ JNK信号通路对黑素生成的影响。

尽管已经研究了印度菊花（CL）的几种生理作用，但是CL作为皮肤健康功能性食品原料的具体作用和分子机理仍然未知。在此，观察到通过CL水提取物（CLE）处理抑制了α-MSH和IBMX引发的B16F10黑色素生成。CLE处理还通过发挥TGF-β/ JNK信号通路提高了前胶原1α2，胶原1α2和纤连蛋白的mRNA表达水平。总之，通过下调黑色素生成和增强皮肤原纤维相关基因，证明了CLE在皮肤健康中的有益作用。还揭示了CLE的功能通过TGF-β/ JNK信号传导途径的激活来介导。