Carbon nanodots (C‐dots) are emerging as a new type of promising agent in anticancer, imaging, and new energy. Reports as well as the previous research indicate that certain C‐dots can enhance targeted cancer therapy. However, in‐depth mechanisms for such anticancer effect remain unclear. In this work, treatment provided by the date pit‐derived C‐dots, exhibits significant DNA damage; Annexin V/7‐AAD‐mediated apoptosis, and G2/M cell cycle arrest in prostate cancer cells. The application of C‐dots to the cell generally leads to acidulation of the cell medium, cooperated with membrane compact. The date pit‐derived C‐dots are observed inhibiting the horseradish peroxidase. Moreover, the C‐dots disrupt likely through nucleotide excision DNA repair at low dose during DNA ligation step suggesting the antimicrobial effect and targeting Pim‐1, EGFR, mTOR, and DNA damage pathways in cancer cells. For the first time the detailed and novel mechanisms underlying the C‐dots, derived from the date‐pit, as an efficient, low‐cost, and green nanomaterial are reveled for cancer therapy and anti‐infection.

中文翻译：

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枣核碳点可诱导过氧化物酶的酸性抑制并破坏抗菌抗性中的 DNA 修复。


碳纳米点（C-dots）正在成为抗癌、成像和新能源领域一种有前景的新型制剂。报告以及之前的研究表明，某些碳点可以增强靶向癌症治疗。然而，这种抗癌作用的深层机制仍不清楚。在这项工作中，由枣核衍生的碳点提供的治疗表现出显着的 DNA 损伤；前列腺癌细胞中膜联蛋白 V/7-AAD 介导的细胞凋亡和 G2/M 细胞周期停滞。将碳点应用于细胞通常会导致细胞培养基酸化，并与膜致密物配合。观察到源自枣核的碳点抑制辣根过氧化物酶。此外，在 DNA 连接步骤中，C 点可能通过低剂量的核苷酸切除 DNA 修复而破坏，这表明其具有抗菌作用，并针对癌细胞中的 Pim-1、EGFR、mTOR 和 DNA 损伤途径。源自枣核的碳点作为一种高效、低成本的绿色纳米材料，首次揭示了其详细而新颖的机制，可用于癌症治疗和抗感染。