Introduction. The aim of this meta-analysis was to evaluate the effects of STN DBS on sleep quality and restless leg symptoms in individuals with PD. Methods. We searched the PubMed, Web of Science, EMBASE, CNKI, and WANFANG databases published between 1990 and 2019. The articles included were those that contained both pre- and postsurgery data acquired using International RLS Study Group criteria and the Pittsburgh sleep quality index (PSQI) questionnaire with patients’ follow-up of at least three months. All studies that met the quality requirements were included in a meta-analysis performed using STATA 12.0 software. Results. Of 73 articles identified, 7 studies comprising 82 patients were qualified for the current meta-analysis. After adjusting for heterogeneity in study effect sizes, the random effects meta-analysis indicated that STN DBS improved sleep quality and restless leg symptoms significantly (SMD = −1.111, 95% CI: −1.918∼−0.304, ). Subgroup analysis showed that different sleep scoring criteria had different effects on the condition of sleeping after surgery. Conclusions. STN DBS is a powerful method in the management of sleep quality and restless leg symptoms in PD patients, but its long-term effects with larger populations must be thoroughly assessed.

中文翻译：

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改善帕金森病睡眠症状中的丘脑底核深部脑刺激：荟萃分析。

简介。这项荟萃分析的目的是评估 STN DBS 对 PD 患者睡眠质量和不安腿症状的影响。方法。我们检索了 1990 年至 2019 年间发表的 PubMed、Web of Science、EMBASE、CNKI 和万方数据库。纳入的文章包含使用国际 RLS 研究组标准和匹兹堡睡眠质量指数 (PSQI) 获得的术前和术后数据。 ) 对患者进行至少三个月随访的问卷调查。所有符合质量要求的研究都包含在使用 STATA 12.0 软件进行的荟萃分析中。结果. 在确定的 73 篇文章中，包含 82 名患者的 7 项研究符合当前荟萃分析的条件。在调整了研究效应量的异质性后，随机效应荟萃分析表明，STN DBS 显着改善了睡眠质量和不宁腿症状（SMD = -1.111, 95% CI: -1.918∼-0.304, ）。亚组分析显示，不同的睡眠评分标准对术后睡眠状况的影响不同。结论。STN DBS 是管理 PD 患者睡眠质量和不安腿症状的有效方法，但必须彻底评估其对更大人群的长期影响。