Abstract: Polyphenols are a broad group of substances with potential health benefits found in plant species. Several of these compounds are capable of influencing the activation of intracellular signaling pathways, such as NF-kB, MAPK and JAK-STAT, responsible for the production of various inflammatory mediators such as tumor necrosis factor α (TNF-α) and interleukin 1 beta (IL-1β) and 12 (IL-12), enzymes involved in the production of reactive species such as inducible nitric oxide synthase (iNOS) and superoxide dehydrogenase (SOD), as well as enzymes involved in the production of eicosanoids, such as cyclooxygenase (COX) and lipoxygenase (LO). There is increased interest in the use of polyphenol-rich foods because of their immunomodulatory effect; however, the mechanisms used during macrophage responses are extremely complex and little is known about the effects of polyphenols on these cells. As such, this review summarizes the current view of polyphenol influences on macrophages.

Keywords: polyphenols, inflammation, macrophage activation, cytokine modulation


中文翻译：

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多酚对吞噬细胞功能的影响。

摘要：多酚是植物物种中具有潜在健康益处的多种物质。这些化合物中的几种能够影响细胞内信号传导途径的激活，例如NF-kB，MAPK和JAK-STAT，它们负责产生各种炎症介质，例如肿瘤坏死因子α（TNF-α）和白介素1 beta （IL-1β）和12（IL-12），涉及产生反应性物种的酶，例如诱导型一氧化氮合酶（iNOS）和超氧化物脱氢酶（SOD），以及涉及生产类花生酸的酶，例如环氧合酶（COX）和脂氧合酶（LO）。由于它们的免疫调节作用，人们对使用富含多酚的食物的兴趣日益浓厚。然而，巨噬细胞反应过程中使用的机制极为复杂，对多酚对这些细胞的影响知之甚少。因此，本综述总结了多酚对巨噬细胞影响的当前观点。

关键词：多酚炎症巨噬细胞活化细胞因子调节