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Low-Magnitude, High-Frequency Vibration Promotes Osteogenic Differentiation via Intensifying miRNA-335-5p Expression.
Journal of Environmental Pathology, Toxicology and Oncology ( IF 2.1 ) Pub Date : 2019-11-05 , DOI: 10.1615/jenvironpatholtoxicoloncol.2019030625
Wei Zhao 1 , Yi Tang 1 , Yang Yang 1 , Min Wang 1 , Haiyang Yu 1
Affiliation  

Certain mechanical stimuli-particularly low-magnitude, high-frequency vibration-could induce bone marrow stem cell osteogenic differentiation and promote bone formation via Wnt signaling pathway, although the molecular mechanism is still unclear. In this study, we found that miR-335-5p is significantly upregulated after low-magnitude, high-frequency vibration, which suppresses the expression of the Wnt signaling inhibitor Dickkopf-related protein 1. Inhibition of miR-335-5p greatly reduced the osteogenic differentiation. Furthermore, the increase of miR-335-5p level was also confirmed in vivo after LMHF vibration in rabbit. Our study elucidates the prominent role of miRNAs that links the LMHF vibration and osteogenic differentiation.

中文翻译:

低强度,高频振动通过增强miRNA-335-5p表达促进成骨分化。

某些机械刺激,特别是低振幅,高频振动,可能通过Wnt信号通路诱导骨髓干细胞成骨分化并促进骨形成,尽管其分子机制仍不清楚。在这项研究中,我们发现miR-335-5p在低强度,高频振动后显着上调,从而抑制了Wnt信号抑制剂Dickkopf相关蛋白1的表达。抑制miR-335-5p可以大大降低成骨分化。此外,在兔体内LMHF振动后,体内也证实了miR-335-5p水平的升高。我们的研究阐明了将LMHF振动和成骨分化联系起来的miRNA的显着作用。
更新日期:2019-11-01
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