Fucoxanthin, a potent carotenoid present in various natural sources especially from seaweeds; it exhibits several biological effects like anti-neoplastic, anti-mutagenic, anti-diabetic, anti-obesity and anti-inflammatory actions. Fucoxanthin role in chemoprevention of lung cancer in mouse model induced using benzo(a)pyrene [B(a)P] has been presented here. Oral administration of fucoxanthin with and without B(a)P were studied, the results from our study shows that fucoxanthin significantly decreased tumor progression in mice exposed to B(a)P, the obtained data were correlated with increased antioxidant, apoptosis and decreased tumour marker and anti-apoptotic molecules. With respect to apoptosis, fucoxanthin treated animals shows increased apoptosis compared to tumor induced mice by increased expression of caspase 9 and 3 and decreased expression of anti-apoptotic Bcl2 protein. Finally, histopathological and immuno histochemical analysis also revealed that fucoxanthin shows potent anticancer agent by bringing back the damaged tissue treated with B(a)P and also decreases the expression of PCNA in cancer induced mice. The anticancer effect of fucoxanthin may be attributed by several independent mechanisms which play a important roles in the prevention of cancer development, there is also substantial evidences to show that fucoxanthin acts indirectly by increasing the antioxidant capacity of affected tissue and prepared to cope up with oxidative stress which is proved in our study. Thus from our study it is clearly established that fucoxanthin act as a persuasive anticancer drug against lung cancer.

中文翻译：

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岩藻黄质对小鼠苯并（A）P诱导的肺癌的抗炎和凋亡信号转导作用。

岩藻黄质，一种有效的类胡萝卜素，存在于各种天然来源，尤其是海藻中；它具有多种生物学效应，例如抗肿瘤，抗诱变，抗糖尿病，抗肥胖和抗炎作用。此处介绍了黄嘌呤黄嘌呤在用苯并（a）py [B（a）P]诱导的小鼠模型中化学预防肺癌的作用。研究了含和不含B（a）P的岩藻黄质的口服给药，我们的研究结果表明，岩藻黄质显着降低了接触B（a）P的小鼠的肿瘤进程，获得的数据与抗氧化剂增加，细胞凋亡和肿瘤减少有关标记和抗凋亡分子。关于细胞凋亡 与肿瘤诱导的小鼠相比，通过岩藻黄质处理的动物通过增加caspase 9和3的表达以及降低抗凋亡的Bcl2蛋白的表达而显示出凋亡增加。最后，组织病理学和免疫组织化学分析还表明，岩藻黄质通过将用B（a）P处理的受损组织带回，从而显示出有效的抗癌剂，并且还降低了癌症诱发小鼠的PCNA表达。岩藻黄质的抗癌作用可能归因于几种独立的机制，这些机制在预防癌症的发展中起着重要作用，也有大量证据表明岩藻黄质通过增加患病组织的抗氧化能力而间接发挥作用，并准备应对氧化作用。我们的研究证明了压力。