UNCI 19 expression has been reported to be significantly higher in hepatic cancer cells (HCC). However, the clinical significance of modulating UNC119 expression in HCC is not well understood. The study described here aimed to explore the potential of curcumin in modulation of UNC119 expression in HCC by assessment with quantitative real-time PCR, western blot, and immune-histochemical analyses in HCC cell lines and tissues. The biological functions of UNC119 in the proliferation, growth, and cycle of tumor cells were analyzed both in vitro and in vivo. UNC119 expression was upregulated in HCC cell lines and tissues as indicated by comparison with normal liver cells and tissues. Cellular function assays showed that higher levels of UNC119 not only promoted proliferation but also enhanced HCC cell migration and invasion. UNC119 promoted progression of the cell cycle and significantly promoted HCC cell growth through the Wnt/β-catenin signal pathway, and enhanced tumor migration and invasion by the TGF-β/EMT pathway. Curcumin efficiently inhibited HCC cell proliferation by blocking the Wnt/β-catenin pathway and inhabited migration and invasion by blocking the TGF-p/EMT signal pathway. Curcumin not only was beneficial for tumor remission but also contributed to the long-term survival of HCC-bearing mice. UNC119 was significantly upregulated and promoted cell growth in hepatic cancer cells and tissues by the Wnt/β-catenin signal pathway and migration by TGF-β/EMT signal pathway. Curcumin treatment inhibited cell proliferation, growth, migration, and invasion by inhibition of those pathways.

中文翻译：

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姜黄素通过减少UNC119表达来调节肝细胞癌。

据报道，UNCI 19在肝癌细胞（HCC）中的表达明显更高。但是，尚不十分了解调节HCC中UNC119表达的临床意义。此处描述的研究旨在通过定量实时PCR，western印迹和HCC细胞系和组织的免疫组织化学分析评估姜黄素在HCC UNC119表达调节中的潜力。UNC119在肿瘤细胞的增殖，生长和周期中的生物学功能已在体外和体内进行了分析。与正常肝细胞和组织相比，UNC119表达在HCC细胞系和组织中上调。细胞功能测定表明，更高水平的UNC119不仅促进增殖，而且增强HCC细胞迁移和侵袭。UNC119通过Wnt /β-catenin信号途径促进细胞周期进程并显着促进HCC细胞生长，并通过TGF-β/ EMT途径促进肿瘤迁移和侵袭。姜黄素通过阻断Wnt /β-catenin途径有效抑制HCC细胞增殖，并通过阻断TGF-p / EMT信号途径来抑制迁移和侵袭。姜黄素不仅有益于肿瘤的缓解，而且有助于荷肝癌小鼠的长期存活。UNC119通过Wnt /β-catenin信号途径显着上调并促进肝癌细胞和组织中的细胞生长，并通过TGF-β/ EMT信号途径迁移。姜黄素治疗通过抑制这些途径来抑制细胞增殖，生长，迁移和侵袭。