Merging 1D and 3D genomic information: Challenges in modelling and validation.,Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

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Merging 1D and 3D genomic information: Challenges in modelling and validation.
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms ( IF 2.6 ) Pub Date : 2019-10-28 , DOI: 10.1016/j.bbagrm.2019.194415
Alessandra Merlotti ₁ , Angelo Rosa ₂ , Daniel Remondini ₁

Affiliation

Genome organization in eukaryotes during interphase stems from the delicate balance between non-random correlations present in the DNA polynucleotide linear sequence and the physico/chemical reactions which shape continuously the form and structure of DNA and chromatin inside the nucleus of the cell. It is now clear that these mechanisms have a key role in important processes like gene regulation, yet the detailed ways they act simultaneously and, eventually, come to influence each other even across very different length-scales remain largely unexplored. In this paper, we recapitulate some of the main results concerning gene regulatory and physical mechanisms, in relation to the information encoded in the 1D sequence and the 3D folding structure of DNA. In particular, we stress how reciprocal crossfeeding between 1D and 3D models may provide original insight into how these complex processes work and influence each other. This article is part of a Special Issue entitled: Transcriptional Profiles and Regulatory Gene Networks edited by Dr. Dr. Federico Manuel Giorgi and Dr. Shaun Mahony.

中文翻译：

合并1D和3D基因组信息：建模和验证方面的挑战。

真核生物在相间期的基因组组织源自DNA多核苷酸线性序列中存在的非随机相关性与物理/化学反应之间的微妙平衡，所述物理/化学反应连续地塑造细胞核内DNA和染色质的形式和结构。现在清楚的是，这些机制在诸如基因调控等重要过程中起着关键作用，但是它们同时发挥作用并最终甚至在非常不同的长度范围内相互影响的详细方式仍未得到充分探索。在本文中，我们概述了有关基因调控和物理机制的一些主要结果，这些结果与DNA的1D序列和3D折叠结构中编码的信息有关。特别是，我们强调一维和3D模型之间的相互交叉馈送如何提供这些复杂过程如何工作以及如何相互影响的原始见解。本文是由Federico Manuel Giorgi博士和Shaun Mahony博士编辑的《转录概况和调控基因网络》特刊的一部分。

更新日期：2020-03-26

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