Gabapentin is one of the most used drugs to treat postoperative pain with antihyperalgesic properties and has a unique mechanism of action, which differentiates it from other commonly used drugs. Various studies have shown that the perioperative use of gabapentin reduces postoperative pain. In our study, fragments of gingival tissue of healthy volunteers were collected during operation. Gene expression of 29 genes was investigated in gingival fibroblasts cell culture treated with gabapentin, compared with untreated cells. Of the different chemokines and interleukins studied, only 10 were statistically significant (CCL1, CCR1, CCR4, CCR5, CCR6, ILI1A, ILI1B, IL5, IL6R, TNFSF10). The overexpression of these cytokines, obtained in many studies, leads us to think that gabapentin can interact and cause post-inflammatory gingival hyperplasia, but, probably, in our study the gabapentin has not the same effect, because we used gingival fibroblasts of healthy people.

中文翻译：

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加巴喷丁影响健康牙龈细胞上炎症介质的表达。

加巴喷丁是具有抗痛觉过敏特性的治疗术后疼痛的最常用药物之一，并且具有独特的作用机制，使其与其他常用药物区别开来。各种研究表明，围手术期使用加巴喷丁可以减轻术后疼痛。在我们的研究中，在手术过程中收集了健康志愿者的牙龈组织碎片。与未处理的细胞相比，在用加巴喷丁处理的牙龈成纤维细胞培养物中研究了29个基因的基因表达。在研究的不同趋化因子和白介素中，只有10个具有统计学意义（CCL1，CCR1，CCR4，CCR5，CCR6，ILI1A，ILI1B，IL5，IL6R，TNFSF10）。在许多研究中获得的这些细胞因子的过表达使我们认为加巴喷丁可以相互作用并引起炎症后牙龈增生，但是，