The aim of this study was to evaluate the abatement power of oral microbial loading of a new gel formulation based on the complex silver-2-mercaptobenzoate, chlorhexidine digluconate and didecyldimethylammonium chloride (named ADC) through polymerase chain reaction (PCR). The study sample consists of a group of 20 patients with chronic periodontal disease. Patients were over 25 years of age and did not undergo surgical or non-surgical periodontal treatment in the previous 6 months. The study sample was allotted into two groups of 10 patients each, homogeneous by age and sex. The test group received a bottle containing ADC gel, while the control group received an identical one containing placebo, similar to ADC in consistence, colour, taste and odour. Sub-gingival samples of four sites, one in each quadrant, of greatest probing depth in each patient were used. Microbiological analyses were performed at baseline and at day 15. Paired t test was performed to detect statistical significant reduction in total bacterial loading and oral pathogens in the study groups. The analysis showed a statistically significant reduction in the total bacterial loading evaluated pre- and post-treatment (P = 0.029) in the study groups. In the control group, the decrease in total bacterial loading was not significant (P = 0.279). Clinically, ADC gel does not have any side effects and discomfort such as pain, burning, tingling sensation or numbness and produces no adverse reactions in time. Our study aimed to evaluate the efficacy of a new chemical formulation with antibacterial properties to use for daily oral hygiene with a preliminary study. Our results showed a statistically significant reduction in total bacterial loading after treatment, but the limitations of our study do not allow us to demonstrate the clinical efficacy of the ADC gel.

中文翻译：

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基于银和阳离子表面活性剂的新型化学装置作为日常口腔卫生的一种新方法：对一组牙周患者的初步研究。

这项研究的目的是通过聚合酶链反应（PCR）评估基于复合2-巯基苯甲酸银，氯己定二葡萄糖酸酯和二癸基二甲基氯化铵（ADC）的新型凝胶制剂的口服微生物负荷减轻能力。该研究样本由20名患有慢性牙周疾病的患者组成。患者年龄超过25岁，并且在过去6个月内未接受手术或非手术牙周治疗。将研究样本分为两组，每组10名患者，按年龄和性别划分。测试组接受一瓶装有ADC凝胶的瓶子，而对照组接受相同的装有安慰剂的瓶子，其稠度，颜色，味道和气味类似于ADC。四个部位的龈下样本，每个象限一个，在每个患者中使用最大探测深度。在基线和第15天进行了微生物学分析。进行配对t检验以检测研究组中总细菌载量和口腔病原体的统计学显着减少。分析表明，在研究组中，治疗前后评估的总细菌载量有统计上的显着降低（P = 0.029）。在对照组中，总细菌载量的减少并不显着（P = 0.279）。临床上，ADC凝胶没有任何副作用和不适，例如疼痛，灼痛，刺痛感或麻木感，并且不会及时产生不良反应。我们的研究旨在通过初步研究评估具有抗菌特性的新型化学制剂用于日常口腔卫生的功效。