In subjects affected by chronic periodontitis, the chemical control of plaque is a strategy aiming primarily at controlling infection and bacterial loading. The aim is to evaluate the bacterial loading of the so-called 'red complex' associated with a short-term use of a hydrosilver gel (HSG) by using an in vivo model in adult subjects affected by chronic periodontitis. This prospective short-term clinical trial involved 10 adult volunteers using a 15-day in vivo model. After receiving professional prophylaxis at baseline (t0), each volunteer performed daily applications of HSG at home. After 15 days (t1) from the first application, subgingival plaque samples were collected, and the bacterial loading of species belonging to the red complex was evaluated using polymerase chain reaction (PCR) analyses. The bacterial loading of the red complex showed no statistically significant difference between t0 and t1, although it tended to decrease. HSG can be used at home as an adjunct to domestic oral care because it seems a promising tool, but further studies are needed to involve a larger sample and a longer follow-up.

中文翻译：

---

在患有慢性牙周炎的成年人中控制斑块的水银凝胶：对“红色复合物”细菌载量的影响。使用聚合酶链反应分析的前瞻性纵向试验研究。

在患有慢性牙周炎的受试者中，斑块的化学控制是主要旨在控制感染和细菌载量的策略。目的是通过在受慢性牙周炎影响的成年受试者中使用体内模型，评估与短期使用水银凝胶（HSG）相关的所谓“红色复合物”的细菌载量。这项前瞻性短期临床试验涉及10位成年志愿者，使用15天体内模型。在基线（t0）接受专业预防后，每个志愿者每天在家中进行HSG的应用。从首次施用起15天（t1）后，收集龈下菌斑样品，并使用聚合酶链反应（PCR）分析评估属于红色复合物的菌种的细菌载量。红色复合物的细菌载量在t0和t1之间没有统计学上的显着差异，尽管它趋于减少。HSG可以在家中作为家庭口腔护理的辅助手段，因为它似乎是一种有前途的工具，但是需要进行更多的研究才能涉及更大的样本量和更长的随访时间。