Only a minority of cancer patients respond to anti PD-1 immunotherapy. A recent study demonstrates that PD-1 therapy-resistant melanoma patients present distinct signatures of upregulated genes involved in immunosuppression, angiogenesis, monocyte and macrophage chemotaxis, extracellular matrix remodeling, and epithelial-mesenchymal transition (EMT). Combination targeting of these pathways with PD-1 may help overcome PD-1 resistance, thus producing effective antitumor immunity.

中文翻译：

---

从PD-1抗性中学习：新的组合策略。

只有少数癌症患者对抗PD-1免疫疗法有反应。最近的一项研究表明，PD-1治疗耐药的黑色素瘤患者表现出与免疫抑制，血管生成，单核细胞和巨噬细胞趋化性，细胞外基质重塑以及上皮-间质转化（EMT）有关的上调基因的独特标志。这些途径与PD-1的联合靶向可能有助于克服PD-1的耐药性，从而产生有效的抗肿瘤免疫力。