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Learning from PD-1 Resistance: New Combination Strategies.
Trends in Molecular Medicine ( IF 11.099 ) Pub Date : 2016-05-14 , DOI: 10.1016/j.molmed.2016.04.008
Xia Bu,Kathleen M Mahoney,Gordon J Freeman

Only a minority of cancer patients respond to anti PD-1 immunotherapy. A recent study demonstrates that PD-1 therapy-resistant melanoma patients present distinct signatures of upregulated genes involved in immunosuppression, angiogenesis, monocyte and macrophage chemotaxis, extracellular matrix remodeling, and epithelial-mesenchymal transition (EMT). Combination targeting of these pathways with PD-1 may help overcome PD-1 resistance, thus producing effective antitumor immunity.
更新日期:2016-05-09

 

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